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  • Deprecated function: Return type of DatabaseStatementBase::execute($args = [], $options = []) should either be compatible with PDOStatement::execute(?array $params = null): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 2244 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/database/database.inc).
  • Deprecated function: Return type of DatabaseStatementEmpty::current() should either be compatible with Iterator::current(): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 2346 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/database/database.inc).
  • Deprecated function: Return type of DatabaseStatementEmpty::next() should either be compatible with Iterator::next(): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 2346 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/database/database.inc).
  • Deprecated function: Return type of DatabaseStatementEmpty::key() should either be compatible with Iterator::key(): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 2346 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/database/database.inc).
  • Deprecated function: Return type of DatabaseStatementEmpty::valid() should either be compatible with Iterator::valid(): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 2346 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/database/database.inc).
  • Deprecated function: Return type of DatabaseStatementEmpty::rewind() should either be compatible with Iterator::rewind(): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 2346 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/database/database.inc).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in drupal_random_bytes() (line 2268 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/bootstrap.inc).
  • Deprecated function: Optional parameter $data declared before required parameter $name is implicitly treated as a required parameter in require_once() (line 341 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/module.inc).
  • Deprecated function: Optional parameter $data declared before required parameter $name is implicitly treated as a required parameter in require_once() (line 341 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/module.inc).
  • Deprecated function: Optional parameter $file declared before required parameter $entity_type is implicitly treated as a required parameter in require_once() (line 341 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/module.inc).
  • Deprecated function: Optional parameter $account declared before required parameter $entity_type is implicitly treated as a required parameter in require_once() (line 341 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/module.inc).
  • Deprecated function: Optional parameter $entity declared before required parameter $entity_type is implicitly treated as a required parameter in require_once() (line 341 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/module.inc).
  • Deprecated function: Optional parameter $account declared before required parameter $entity_type is implicitly treated as a required parameter in require_once() (line 341 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/module.inc).
  • Deprecated function: Optional parameter $values declared before required parameter $entity_type is implicitly treated as a required parameter in require_once() (line 341 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/module.inc).
  • Deprecated function: Optional parameter $view_mode declared before required parameter $entity_type is implicitly treated as a required parameter in require_once() (line 341 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/module.inc).
  • Deprecated function: Optional parameter $langcode declared before required parameter $entity_type is implicitly treated as a required parameter in require_once() (line 341 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/module.inc).
  • Deprecated function: rtrim(): Passing null to parameter #1 ($string) of type string is deprecated in url() (line 2349 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/common.inc).
  • Deprecated function: strpos(): Passing null to parameter #1 ($haystack) of type string is deprecated in url_is_external() (line 2393 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/common.inc).
  • Deprecated function: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in url_is_external() (line 2395 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/common.inc).
  • Deprecated function: ltrim(): Passing null to parameter #1 ($string) of type string is deprecated in url() (line 2311 of /srv/data/web/vhosts/www.entromics.com/htdocs/includes/common.inc).

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Comparison of Personalized Network Medicine to typical existing data processing paradigm:

 

 

Maximal entropy principle guarantees that no other method can extract more relevant clinical information than Personalized Network Medicine.

Mathematical validation of this statement is briefly summarized here.

Key to the direct clinical relevance of PNM is the maximal compatibility of generated models with the actual observed clinical data:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Personalized Network Medicine
Network Phenotyping Strategy
Entromics